PAT-505
Modify Date: 2024-04-02 08:15:44
PAT-505 structure
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Common Name | PAT-505 | ||
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| CAS Number | 1782070-85-2 | Molecular Weight | 495.905 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H17ClF2N3NaO2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PAT-505PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX; displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ; maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively; robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH. |
| Name | PAT-505 |
|---|
| Description | PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX; displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ; maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively; robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH. |
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| References | References 1. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. View Related Products by Target Autotaxin |
| Molecular Formula | C23H17ClF2N3NaO2S |
|---|---|
| Molecular Weight | 495.905 |