1782070-85-2
1782070-85-2 structure
- Name: PAT-505
- Chemical Name: PAT-505
- CAS Number: 1782070-85-2
- Molecular Formula: C23H17ClF2N3NaO2S
- Molecular Weight: 495.905
- Create Date: 2020-01-12 11:19:50
- Modify Date: 2024-04-02 08:15:44
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PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX; displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ; maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively; robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH.
| Name | PAT-505 |
|---|
| Description | PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX; displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ; maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively; robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH. |
|---|---|
| References | References 1. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. View Related Products by Target Autotaxin |
| Molecular Formula | C23H17ClF2N3NaO2S |
|---|---|
| Molecular Weight | 495.905 |