AUTEN-67

Modify Date: 2024-03-05 10:54:54

AUTEN-67 Structure
AUTEN-67 structure
Common Name AUTEN-67
CAS Number 1783800-77-0 Molecular Weight 474.445
Density 1.6±0.1 g/cm3 Boiling Point 689.7±65.0 °C at 760 mmHg
Molecular Formula C23H14N4O6S Melting Point N/A
MSDS N/A Flash Point 370.9±34.3 °C

 Use of AUTEN-67


A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.

 Names

Name N-[3-(1H-Benzimidazol-1-yl)-1,4-dioxo-1,4-dihydro-2-naphthalenyl]-4-nitrobenzenesulfonamide
Synonym More Synonyms

 AUTEN-67 Biological Activity

Description A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.
References References 1. Papp D, et al. Autophagy. 2016;12(2):273-86. 2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47. View Related Products by Target Autophagy

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 689.7±65.0 °C at 760 mmHg
Molecular Formula C23H14N4O6S
Molecular Weight 474.445
Flash Point 370.9±34.3 °C
Exact Mass 474.063416
LogP 3.68
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.755

 Synonyms

MFCD30724098
Benzenesulfonamide, N-[3-(1H-benzimidazol-1-yl)-1,4-dihydro-1,4-dioxo-2-naphthalenyl]-4-nitro-
N-[3-(1H-Benzimidazol-1-yl)-1,4-dioxo-1,4-dihydro-2-naphthalenyl]-4-nitrobenzenesulfonamide
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