Name | Trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-in dole]-2,2'''(1H,1'''H)-dione |
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Description | JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1]. |
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Related Catalog | |
Target |
IC50: 1.17μM (Wnt signaling)[1] |
In Vitro | JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin[1]. JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines[1]. JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM[1]. Western Blot Analysis[1] Cell Line: SW480 cells Concentration: 1 μM Incubation Time: 24 hours Result: Increased the AXIN2 expression. RT-PCR[1] Cell Line: SW480 cells Concentration: 10 or 25μM Incubation Time: 72 hours Result: Reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S. |
References |
Molecular Formula | C21H18N2O6 |
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Molecular Weight | 394.37700 |
Exact Mass | 394.11600 |
PSA | 102.10000 |
LogP | 1.84680 |
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
RIDADR | UN 2811 6.1 / PGIII |