PHCCC
Modify Date: 2024-01-02 19:26:15
PHCCC structure
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Common Name | PHCCC | ||
|---|---|---|---|---|
| CAS Number | 179068-02-1 | Molecular Weight | 294.305 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 579.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H14N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 304.0±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of PHCCCPHCCC is a Group I metabotropic glutamate receptor antagonist with EC50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8.target: a Group I metabotropic glutamate receptor antagonistEC 50: 6 uMIn vitro: PHCCC potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. In vivo: 1, PHCCC produced antiparkinsonian efficacy in the reserpinized rat model means a significant level of glutamate is available for the activation of the therapeutically relevant mGluR4. 2, The reference for animal administration is 10 mg/kg.(i.p) 3,PHCCC augmentes in vivo genetic and pharmacological models of absence seizures in rats. |
| Name | (7E)-7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | PHCCC is a Group I metabotropic glutamate receptor antagonist with EC50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8.target: a Group I metabotropic glutamate receptor antagonistEC 50: 6 uMIn vitro: PHCCC potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. In vivo: 1, PHCCC produced antiparkinsonian efficacy in the reserpinized rat model means a significant level of glutamate is available for the activation of the therapeutically relevant mGluR4. 2, The reference for animal administration is 10 mg/kg.(i.p) 3,PHCCC augmentes in vivo genetic and pharmacological models of absence seizures in rats. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 579.1±50.0 °C at 760 mmHg |
| Molecular Formula | C17H14N2O3 |
| Molecular Weight | 294.305 |
| Flash Point | 304.0±30.1 °C |
| Exact Mass | 294.100433 |
| LogP | 1.88 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.700 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| (7E)-7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide |
| Cyclopropa[b][1]benzopyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-, (7E)- |
| PHCCC |