Curzerene

Modify Date: 2024-01-02 11:27:25

Curzerene structure	Common Name	Curzerene
	CAS Number	17910-09-7	Molecular Weight	216.319
	Density	1.0±0.1 g/cm3	Boiling Point	282.8±40.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₀O	Melting Point	N/A
	MSDS	N/A	Flash Point	117.5±14.2 °C

Use of Curzerene

Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1].

Name	isofuranogermacrene
Synonym	More Synonyms

Description	Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase
Target	GSTA1[1]
In Vitro	Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1]. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1]. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1]. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1]. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1]. Cell Viability Assay[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro. Apoptosis Analysis[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced apoptosis of the cells in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced G2/M cell cycle arrest of SPC A1 cells. RT-PCR[1] Cell Line: SPC-A1 cells Concentration: 6.25 µM, 25 µM, 100 µM Incubation Time: 48 hours Result: Decreased GSTA1 mRNA expression.
References	[1]. Wang Y, et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29.

Density	1.0±0.1 g/cm3
Boiling Point	282.8±40.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₀O
Molecular Weight	216.319
Flash Point	117.5±14.2 °C
Exact Mass	216.151413
PSA	13.14000
LogP	5.78
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.539
Storage condition	2-8℃