3-Hydroxy Midostaurin

Modify Date: 2025-08-26 20:48:17

3-Hydroxy Midostaurin Structure
3-Hydroxy Midostaurin structure
Common Name 3-Hydroxy Midostaurin
CAS Number 179237-49-1 Molecular Weight 586.63600
Density N/A Boiling Point N/A
Molecular Formula C35H30N4O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 3-Hydroxy Midostaurin


3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

 Names

Name cgp52421

 3-Hydroxy Midostaurin Biological Activity

Description 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
Related Catalog
Target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1]

In Vitro CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].
References

[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.

 Chemical & Physical Properties

Molecular Formula C35H30N4O5
Molecular Weight 586.63600
Exact Mass 586.22200
PSA 97.96000
LogP 5.72650
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