3-Hydroxy Midostaurin
Modify Date: 2024-01-02 12:12:01
3-Hydroxy Midostaurin structure
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Common Name | 3-Hydroxy Midostaurin | ||
|---|---|---|---|---|
| CAS Number | 179237-49-1 | Molecular Weight | 586.63600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H30N4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 3-Hydroxy Midostaurin3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1]. |
| Name | cgp52421 |
|---|
| Description | 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1]. |
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| Related Catalog | |
| Target |
IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1] |
| In Vitro | CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1]. |
| References |
| Molecular Formula | C35H30N4O5 |
|---|---|
| Molecular Weight | 586.63600 |
| Exact Mass | 586.22200 |
| PSA | 97.96000 |
| LogP | 5.72650 |