LY3104607
Modify Date: 2026-07-08 21:04:06
LY3104607 structure
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Common Name | LY3104607 | ||
|---|---|---|---|---|
| CAS Number | 1795232-22-2 | Molecular Weight | 439.515 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H25N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LY3104607LY3104607 (LY-3104607) is a potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM; demonstrates functional potency and glucose dependent insulin secretion in primary islets from rats; dose-dependently reduces glucose levels in vivo. |
| Name | LY3104607 |
|---|
| Description | LY3104607 (LY-3104607) is a potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM; demonstrates functional potency and glucose dependent insulin secretion in primary islets from rats; dose-dependently reduces glucose levels in vivo. |
|---|---|
| References | References 1. Hamdouchi C, et al. J Med Chem. 2017 Dec 13. doi: 10.1021/acs.jmedchem.7b01411. View Related Products by Target Free Fatty Acid Receptor (FFAR) |
| Molecular Formula | C27H25N3O3 |
|---|---|
| Molecular Weight | 439.515 |
| InChIKey | FDIWCHYTKOPHPS-QFIPXVFZSA-N |
| SMILES | CC#CC(CC(=O)O)c1ccc(OCc2ccc3nc(-c4c(C)cccc4C)nn3c2)cc1 |
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Name: AUC (0 to 24 hrs) in Beagle dog at 100 mg/kg, po
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL4027578
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Name: AUC (0 to 24 hrs) in Beagle dog at 300 mg/kg, po
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL4027579
|
|
Name: AUC (0 to 24 hrs) in Beagle dog at 3 mg/kg, po
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL4027576
|
|
Name: AUC (0 to 24 hrs) in Beagle dog at 30 mg/kg, po
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL4027577
|
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Name: Oral bioavailability in Sprague-Dawley rat at 1 mg/kg
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL4027574
|
|
Name: AUC (0 to 24 hrs) in Beagle dog at 1 mg/kg, iv
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL4027575
|
|
Name: Half life in Sprague-Dawley rat at 1 mg/kg, iv
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL4027572
|
|
Name: Half life in Sprague-Dawley rat at 1 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL4027573
|
|
Name: Tmax in Beagle dog at 30 mg/kg, po
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL4027586
|
|
Name: Tmax in Beagle dog at 100 mg/kg, po
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL4027587
|
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