HPB

Modify Date: 2024-01-02 14:01:44

HPB Structure
HPB structure
Common Name HPB
CAS Number 1800066-24-3 Molecular Weight 328.362
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C18H20N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HPB


HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].

 Names

Name HPB
Synonym More Synonyms

 HPB Biological Activity

Description HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].
Related Catalog
Target

HDAC6:31 nM (IC50)

HDAC1:1130 nM (IC50)

References

[1]. Nicholas J Porter, et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13459-13464.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C18H20N2O4
Molecular Weight 328.362
Exact Mass 328.142303
LogP 0.64
Index of Refraction 1.622

 Synonyms

N-Hydroxy-4-{[(2-hydroxyethyl)(phenylacetyl)amino]methyl}benzamide
N-Hydroxy-4-((N-(2-hydroxyethyl)-2-phenylacetamido)methyl)benzamide
HPB
Benzeneacetamide, N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-N-(2-hydroxyethyl)-