CCR5 antagonist 2
Modify Date: 2025-08-28 09:44:19
CCR5 antagonist 2 structure
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Common Name | CCR5 antagonist 2 | ||
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| CAS Number | 1800570-93-7 | Molecular Weight | 601.79 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H45F2N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CCR5 antagonist 2CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC50 of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities[1]. |
| Name | CCR5 antagonist 2 |
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| Description | CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC50 of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities[1]. |
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| Related Catalog | |
| Target |
CCR5:8.34 nM (IC50) HIV-1:11 nM (EC50, TZM-bl cell) |
| In Vitro | CCR5 antagonist 2 (Compound 25) (48 h) 在 TZM-bl 细胞中表现出优异的 HIV-1 抑制活性，EC50 为 0.011 ± 0.002 μM[1]。 CCR5 antagonist 2 (48 h) 对 TZM-bl 细胞中亲 CCR5 整合酶抑制剂耐药株 HIV-1YU-2(G140S/Q148H) 具有抗病毒活性，EC50 为 4.34 ± 1.61 nM[1]。 CCR5 antagonist 2 对 HIV-1 菌株 KIZ001、YU-2、KIZ006、SF162 和 Ba-L 有抑制作用，EC50 分别为 7.82、8.73、12.61、15.99 和 16.93 nM[1]。 |
| In Vivo | PK Properties of CCR5 antagonist 2 (Compound 25) in SD Rats[1] compd admin dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) AUC0–last (ng·h/mL) AUC0–∞ (ng·h/mL) MRT (h) CL (mL/min/kg) F (%) CCR5 antagonist 2 p.o. 10 49.5 ± 18.6 2.0 ± 0.0 10.3 ± 2.5 229 ± 92 283 ± 105 13.2 ± 4.2 – 15.7 i.v. 2 – – 1.60 ± 0.03 291 ± 75 298 ± 76 1.81 ± 0.04 117 ± 29 Animal Model: SD rats[1] Dosage: 2 mg/kg and 10 mg/kg Administration: Intravenous and oral administration (Pharmacokinetic Analysis) Result: Displayed good PK profiles. |
| References |
| Molecular Formula | C32H45F2N5O2S |
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| Molecular Weight | 601.79 |