Milvexian
Modify Date: 2026-07-02 09:32:00
Milvexian structure
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Common Name | Milvexian | ||
|---|---|---|---|---|
| CAS Number | 1802425-99-5 | Molecular Weight | 626.44 | |
| Density | 1.60±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C28H23Cl2F2N9O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MilvexianMilvexian (BMS-986177), an effective antithrombotic agent, is an orally-bioavailable, reversible and direct inhibitor of human and rabbit factor XIa (FXIa) with Ki of 0.11, and 0.38 nM, respectively[1]. |
| Name | Milvexian |
|---|---|
| Synonym | More Synonyms |
| Description | Milvexian (BMS-986177), an effective antithrombotic agent, is an orally-bioavailable, reversible and direct inhibitor of human and rabbit factor XIa (FXIa) with Ki of 0.11, and 0.38 nM, respectively[1]. |
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| Related Catalog | |
| References |
| Density | 1.60±0.1 g/cm3 |
|---|---|
| Molecular Formula | C28H23Cl2F2N9O2 |
| Molecular Weight | 626.44 |
| InChIKey | FSWFYCYPTDLKON-CMJOXMDJSA-N |
| SMILES | CC1CCCC(n2cnc(-c3cc(Cl)ccc3-n3cc(Cl)nn3)cc2=O)c2cc(ccn2)-c2c(cnn2C(F)F)NC1=O |
| Storage condition | 2-8°C |
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Name: Fraction unbound in Sprague-Dawley rat plasma
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040365
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Name: Metabolic stability in cynomolgus monkey liver microsomes assessed as half life
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040360
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Name: Half life in cynomolgus monkey at 1.50 mg/kg, po or 0.50 mg/kg, iv
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040359
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Name: Oral bioavailability in Sprague-Dawley rat at 1.04 mg/kg
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040358
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Name: Aqueous solubility of the compound at pH 1.0
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040364
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Name: Aqueous solubility of the compound at pH 6.5
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040363
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Name: AUC in cynomolgus monkey at 1.50 mg/kg, po
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040362
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Name: Oral bioavailability in cynomolgus monkey at 1.50 mg/kg
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040361
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Name: Inhibition of Phosphodiesterase (unknown origin) at 16 to 94 ug/ml
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040352
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Name: Volume of distribution at steady state in Sprague-Dawley rat at 1.04 mg/kg, po or 0.5...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5040351
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| BMS-986177 |