CU-3
Modify Date: 2026-07-01 13:10:01
CU-3 structure
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Common Name | CU-3 | ||
|---|---|---|---|---|
| CAS Number | 1815598-71-0 | Molecular Weight | 392.47 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H12N2O4S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CU-3(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (5Z,2E)-CU-3 |
|---|
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. |
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| Related Catalog | |
| Target |
IC50: 0.6 μM (DGKα)[1] |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C16H12N2O4S3 |
|---|---|
| Molecular Weight | 392.47 |
| InChIKey | YIUMXULORVBWLL-SPGDJUBISA-N |
| SMILES | O=C1C(=CC=Cc2ccco2)SC(=S)N1NS(=O)(=O)c1ccccc1 |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Fluorescence polarization-based biochemical high throughput confirmation assay to ide...
Source: The Scripps Research Institute Molecular Screening Center
Target: abhydrolase domain-containing protein 4 isoform 1 [Mus musculus]
External Id: ABHD4_INH_FP_1536_3X%INH CRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of (5Z,2E)-CU-3? |
| A: Molecular formula of (5Z,2E)-CU-3 is C16H12N2O4S3. |
| Q: What is the English name of (5Z,2E)-CU-3? |
| A: The English name of (5Z,2E)-CU-3 is (5Z,2E)-CU-3. |
| Q: What is the molecular weight of (5Z,2E)-CU-3? |
| A: Molecular weight of (5Z,2E)-CU-3 is 392.47. |
| Q: What is the CAS number of (5Z,2E)-CU-3? |
| A: CAS number of (5Z,2E)-CU-3 is 1815598-71-0. |
| Q: What is the InChIKey of (5Z,2E)-CU-3? |
| A: InChIKey of (5Z,2E)-CU-3 is YIUMXULORVBWLL-SPGDJUBISA-N. |
| Q: What is the SMILES notation of (5Z,2E)-CU-3? |
| A: SMILES notation of (5Z,2E)-CU-3 is O=C1C(=CC=Cc2ccco2)SC(=S)N1NS(=O)(=O)c1ccccc1. |
| Q: What is the Chinese name of 1815598-71-0? |
| A: Chinese name of 1815598-71-0 is N-{5-[(E)-3-Furan-2-yl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-benzenesulfonamide. |
| Q: What are the uses of (5Z,2E)-CU-3? |
| A: Main uses of (5Z,2E)-CU-3: (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |