Thymidine-13C10,15N2

Modify Date: 2024-04-03 18:11:48

Thymidine-13C10,15N2 Structure
Thymidine-13C10,15N2 structure
 Common Name Thymidine-13C10,15N2
CAS Number 1821188-00-4 Molecular Weight 254.14
Density N/A Boiling Point N/A
Molecular Formula 13C10H1415N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thymidine-13C10,15N2


Thymidine-13C10,15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

 Names

Name Thymidine-13C10,15N2

 Thymidine-13C10,15N2 Biological Activity

Description Thymidine-13C10,15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17).  

[3]. FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24181(4604):274-5.  

[4]. FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24  

 Chemical & Physical Properties

Molecular Formula 13C10H1415N2O5
Molecular Weight 254.14
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