Arzoxifene

Modify Date: 2025-08-25 13:16:51

Arzoxifene structure	Common Name	Arzoxifene
	CAS Number	182133-25-1	Molecular Weight	475.59900
	Density	1.234g/cm3	Boiling Point	656.4ºC at 760mmHg
	Molecular Formula	C₂₈H₂₉NO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	350.8ºC

Use of Arzoxifene

Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile[1].

Name	2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
Synonym	More Synonyms

Description	Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Metabolic Disease
Target	estrogen[1]
In Vitro	Arzoxifene reduces estrogen receptor expression in endometrial cancer cell lines (ECC-1)[1].
In Vivo	Arzoxifene inhibits MCF-7 breast cancer xenograft growth in oophorectomized athymic mice. Arzoxifene is reported to prevent body weight increase in oophorectomized rats[1].
References	[1]. Jackson LR, et al. Arzoxifene: the evidence for its development in the management of breast cancer. Core Evid. 2008;2(4):251-258.

Density	1.234g/cm3
Boiling Point	656.4ºC at 760mmHg
Molecular Formula	C₂₈H₂₉NO₄S
Molecular Weight	475.59900
Flash Point	350.8ºC
Exact Mass	475.18200
PSA	79.40000
LogP	6.87740
Vapour Pressure	7.85E-18mmHg at 25°C
Index of Refraction	1.635