DPI-3290

Modify Date: 2024-01-09 19:09:24

DPI-3290 structure	Common Name	DPI-3290
	CAS Number	182417-73-8	Molecular Weight	487.60800
	Density	1.161±0.06 g/cm3(Predicted)	Boiling Point	620.4±55.0 °C(Predicted)
	Molecular Formula	C₃₀H₃₄FN₃O₂	Melting Point	144-145 °C
	MSDS	N/A	Flash Point	N/A

Use of DPI-3290

DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively。DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity[1].

Name	3-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-hydroxyphenyl)methyl]-N-(3-fluorophenyl)-N-methylbenzamide
Synonym	More Synonyms

Description	DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively。DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	IC50: 0.18 nM (δ-opioid receptor), 0.46 nM (μ-opioid receptor) and 0.62 nM (κ-opioid receptor)[1]
In Vivo	DPI-3290 (Org 41793) (intravenous; 0.05 mg/kg) produces a 50% antinociceptive response in rats[1].
References	[1]. Gengo PJ, et al. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. J Pharmacol Exp Ther. 2003 Dec;307(3):1221-6.

Density	1.161±0.06 g/cm3(Predicted)
Boiling Point	620.4±55.0 °C(Predicted)
Melting Point	144-145 °C
Molecular Formula	C₃₀H₃₄FN₃O₂
Molecular Weight	487.60800
Exact Mass	487.26400
PSA	47.02000
LogP	5.35370
Storage condition	2-8°C

unii-r3uo4y068s

dpi-3290

DPI-3290

Use of DPI-3290

Names

DPI-3290 Biological Activity

Chemical & Physical Properties

Synonyms