VY-3-135
Modify Date: 2024-01-14 09:40:32
VY-3-135 structure
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Common Name | VY-3-135 | ||
|---|---|---|---|---|
| CAS Number | 1824637-41-3 | Molecular Weight | 429.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H27N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VY-3-135VY-3-135 is an orally active, selective acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 value of 44 nM. VY-3-135 displayes no inhibitory activity towards recombinant human ACSS1 or ACSS3. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. VY-3-135 inhibits triple negative breast cancer (TNBC) tumor growth in mouse ACSS2high but not ACSS2low tumors models[1]. |
| Name | VY-3-135 |
|---|
| Description | VY-3-135 is an orally active, selective acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 value of 44 nM. VY-3-135 displayes no inhibitory activity towards recombinant human ACSS1 or ACSS3. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. VY-3-135 inhibits triple negative breast cancer (TNBC) tumor growth in mouse ACSS2high but not ACSS2low tumors models[1]. |
|---|---|
| Related Catalog | |
| In Vitro | VY-3-135 (0.1, 1 μM; for 24 hours) blocks acetate dependent labeling of palmitate by 13C2-acetate in ACSS2low A7C11 and ACSS2high Brpkp110 cells[1]. |
| In Vivo | VY-3-135 (100 mg/kg/day; PO; 30 days) represses MDA-MB-468 (ACSS2high) tumor growth but is mostly ineffective at blocking WHIM12 (ACSS2low) growth[1]. |
| References |
| Molecular Formula | C26H27N3O3 |
|---|---|
| Molecular Weight | 429.51 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: VY-3-135
- Price: Negotiable
- Purity: 98.56%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: VY-3-135
- Price: $450.0/10mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: ￥4200/5 mg
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