Kendomycin

Modify Date: 2024-01-04 10:43:59

Kendomycin structure	Common Name	Kendomycin
	CAS Number	183202-73-5	Molecular Weight	486.640
	Density	1.2±0.1 g/cm3	Boiling Point	678.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₄₂O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	219.9±25.0 °C

Use of Kendomycin

Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent[1][2].

Name	Kendomycin
Synonym	More Synonyms

Description	Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Yasser A Elnakady, et al. Investigations to the Antibacterial Mechanism of Action of Kendomycin. PLoS One. 2016 Jan 21;11(1):e0146165. [2]. Yu Yuan, et al. Total synthesis of kendomycin: a macro-C-glycosidation approach. J Am Chem Soc. 2004 Nov 17;126(45):14720-1. [3]. Tetsuya Sengoku, et al. Total synthesis of the antibiotic kendomycin: a macrocyclization using the Tsuji-Trost etherification. Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4213-6.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> CGRP Receptor

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> CGRP Receptor

Research Areas >> Infection

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Yasser A Elnakady, et al. Investigations to the Antibacterial Mechanism of Action of Kendomycin. PLoS One. 2016 Jan 21;11(1):e0146165.

[2]. Yu Yuan, et al. Total synthesis of kendomycin: a macro-C-glycosidation approach. J Am Chem Soc. 2004 Nov 17;126(45):14720-1.

[3]. Tetsuya Sengoku, et al. Total synthesis of the antibiotic kendomycin: a macrocyclization using the Tsuji-Trost etherification. Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4213-6.

Density	1.2±0.1 g/cm3
Boiling Point	678.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₉H₄₂O₆
Molecular Weight	486.640
Flash Point	219.9±25.0 °C
Exact Mass	486.298126
PSA	96.22000
LogP	5.94
Vapour Pressure	0.0±4.7 mmHg at 25°C
Index of Refraction	1.576

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 10
CAS#:1220044-85-8 CAS#:808766-09-8 CAS#:853995-85-4 CAS#:853995-88-7 (2S,3R,6S)-3-hy...
CAS#:853995-97-8 2-bromo-6-hydro... CAS#:853995-87-6 2-bromo-6-((ter... CAS#:853995-98-9 (S)-4-benzyl-3-... CAS#:853995-99-0 (2R,5S,6R)-2-(2...
CAS#:853995-90-1 (2R,3S,6R)-6-(2... CAS#:853995-89-8 (3-bromo-4,6-di...
DownStream 0

Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces. . Zeeck, A. , and Bode, H.B.

J. Chem. Soc. Perkin Trans. I , 323, (2000)

(1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-Trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.1.0]tetracosa-2,5,7,14-tetraen-4-one

kendomycin from streptomyces violaceoruber

Kendomycin

1,19:5,9-Diepoxybenzocyclooctadecen-3(5H)-one, 6,7,8,9,10,11,12,15,16,17,18,19-dodecahydro-4,7,19-trihydroxy-2,6,8,12,14,16,18-heptamethyl-, (5R,6R,7S,8R,9R,12S,13E,16S,18S,19S)-

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: KENDOMYCIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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