(R)-MLT-985

Modify Date: 2024-01-09 15:13:46

(R)-MLT-985 Structure
(R)-MLT-985 structure
Common Name (R)-MLT-985
CAS Number 1832577-07-7 Molecular Weight 448.27
Density N/A Boiling Point N/A
Molecular Formula C17H15Cl2N9O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (R)-MLT-985


(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells[1].

 Names

Name (R)-MLT-985

 (R)-MLT-985 Biological Activity

Description (R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells[1].
Related Catalog
References

[1]. Jean Quancard, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608.

 Chemical & Physical Properties

Molecular Formula C17H15Cl2N9O2
Molecular Weight 448.27
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