Bakkenolide B
Modify Date: 2024-01-11 19:24:21
Bakkenolide B structure
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Common Name | Bakkenolide B | ||
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| CAS Number | 18455-98-6 | Molecular Weight | 390.470 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 503.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H30O6 | Melting Point | 101-102 °C | |
| MSDS | N/A | Flash Point | 217.1±30.2 °C | |
Use of Bakkenolide BBakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1]. |
| Name | (3R,3'R,3a'R,4'S,7'S,7a'R)-3'-Acetoxy-7',7a'-dimethyl-4-methylene-2-oxodecahydrospiro[furan-3,2'-inden]-4'-yl (2Z)-2-methyl-2-butenoate |
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| Synonym | More Synonyms |
| Description | Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma[1]. |
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| Related Catalog | |
| In Vitro | Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner[1]. Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages[1]. Western Blot Analysis[1] Cell Line: Mouse peritoneal macrophages Concentration: 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml Incubation Time: 1 h later stimulated with LPS Result: Decreased iNOS and cox-2 protein expression. |
| In Vivo | Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice[1]. Animal Model: Ovalbumin-induced asthma mice[1] Dosage: 1 mg/ml Administration: Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30 Result: Exhibited anti-allergic effects in mice. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 503.0±50.0 °C at 760 mmHg |
| Melting Point | 101-102 °C |
| Molecular Formula | C22H30O6 |
| Molecular Weight | 390.470 |
| Flash Point | 217.1±30.2 °C |
| Exact Mass | 390.204254 |
| LogP | 4.07 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.526 |
| (3R,3'R,3a'R,4'S,7'S,7a'R)-3'-Acetoxy-7',7a'-dimethyl-4-methylene-2-oxodecahydrospiro[furan-3,2'-inden]-4'-yl (2Z)-2-methyl-2-butenoate |
| 2-Butenoic acid, 2-methyl-, (3R,3'R,3a'R,4'S,7'S,7a'R)-3'-(acetyloxy)decahydro-7',7'a-dimethyl-4-methylene-2-oxospiro[furan-3(2H),2'-[2H]inden]-4'-yl ester, (2Z)- |