NNC 05-2090

Modify Date: 2023-01-17 21:23:28

NNC 05-2090 structure	Common Name	NNC 05-2090
	CAS Number	184845-43-0	Molecular Weight	414.54
	Density	N/A	Boiling Point	643.1ºC at 760 mmHg
	Molecular Formula	C₂₇H₃₀N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	342.7ºC

Use of NNC 05-2090

NNC 05-2090 is a potent inhibitor of mGAT2, with a Ki of 1.4 μM. Anticonvulsant properties[1].

Name	1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol,hydrochloride
Synonym	More Synonyms

Description	NNC 05-2090 is a potent inhibitor of mGAT2, with a Ki of 1.4 μM. Anticonvulsant properties[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	NNC 05-2090呈剂量依赖性，对DBA/2小鼠的声诱发强直和阵挛惊厥有抑制作用，其ED50值为19 μmol/kg[2]。 NNC 05-2090呈剂量依赖性，在最大电休克（MES）实验中拮抗强直后肢扩展反应，其ED50值为73 mmol/kg[2]。 NNC 05-2090在最高剂量（72-242 mmol/kg）明显（P<0.05）降低了全身性癫痫的严重程度（癫痫分级为3-5级），并且在这些剂量下NNC 05-2090也显著缩短了后放电持续时间（P<0.05）[2]。
References	[1]. C Thomsen, et al. 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br J Pharmacol. 1997 Mar;120(6):983-5. [2]. N O Dalby, et al. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 1997 Jul;28(1):51-61.

Boiling Point	643.1ºC at 760 mmHg
Molecular Formula	C₂₇H₃₀N₂O₂
Molecular Weight	414.54
Flash Point	342.7ºC
Exact Mass	450.20700
PSA	37.63000
LogP	5.91670
Vapour Pressure	2.04E-17mmHg at 25°C

NNC 05-2090 hydrochloride

DC Chemicals Limited
China
Product Name: NNC052090
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

NNC 05-2090 suppliers

NNC 05-2090 price