NNC 26-9100

Modify Date: 2024-01-02 14:47:24

NNC 26-9100 Structure
NNC 26-9100 structure
Common Name NNC 26-9100
CAS Number 199522-35-5 Molecular Weight 556.35
Density 1.482g/cm3 Boiling Point 731.167ºC at 760 mmHg
Molecular Formula C22H25BrCl2N6S Melting Point N/A
MSDS N/A Flash Point 395.996ºC

 Use of NNC 26-9100


NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM). NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning[1][2].

 Names

Name NNC 26-9100,1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
Synonym More Synonyms

 NNC 26-9100 Biological Activity

Description NNC 26-9100 is a selective somatostatin sst4 receptor full agonist (Ki: 6 nM, EC50: 2 nM). NNC 26-9100 decreases total soluble Aβ42, increases brain neprilysin activity and improves learning[1][2].
Related Catalog
References

[1]. Michael Ankersen, et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity. J. Am. Chem. Soc. 1998, 120, 7, 1368-1373.

[2]. Sandoval KE, et al. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 Jul 3;1520:145-56.  

 Chemical & Physical Properties

Density 1.482g/cm3
Boiling Point 731.167ºC at 760 mmHg
Molecular Formula C22H25BrCl2N6S
Molecular Weight 556.35
Flash Point 395.996ºC
Exact Mass 554.04200
PSA 100.96000
LogP 6.14940
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.668

 Synonyms

Pam3CSK4 Biotin
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