Amyloid β-Protein (29-40)

Modify Date: 2024-01-09 21:50:21

Amyloid β-Protein (29-40) Structure
Amyloid β-Protein (29-40) structure
Common Name Amyloid β-Protein (29-40)
CAS Number 184865-04-1 Molecular Weight 1085.36000
Density N/A Boiling Point N/A
Molecular Formula C49H88N12O13S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Amyloid β-Protein (29-40)


β-Amyloid (29-40) is a fragment of Amyloid-β peptide.

 Names

Name amyloid β-protein(30-40)
Synonym More Synonyms

 Amyloid β-Protein (29-40) Biological Activity

Description β-Amyloid (29-40) is a fragment of Amyloid-β peptide.
Related Catalog
Target

Amyloid-β[1]

In Vitro β-Amyloid (29-40) is a fragment of Amyloid-β peptide, unsoluble in water, acetonitrile or in a mixture of both in different ratios. Cationic arginine residues is introduced at β-Amyloid (29-40) C-terminus to solubilize β-Amyloid (29-40) and introduce cationicity in this Aβ stretch to enable it to interact with the negatively charged membrane of bacteria. β-Amyloid (29-40) variants shows antimicrobial effect[1]. Single chain variable fragments (scFv's) binds the 17-28 region of Abeta and effectively inhibits in vitro aggregation of Abeta, but binding the carboxyl-terminal region of β-Amyloid (29-40) does not inhibit aggregation[2].
References

[1]. Harioudh MK, et al. A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity. Chem Commun (Camb). 2017 Dec 5;53(97):13079-13082.

[2]. Liu R, et al. Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry. 2004 Jun 8;43(22):6959-67.

 Chemical & Physical Properties

Molecular Formula C49H88N12O13S
Molecular Weight 1085.36000
Exact Mass 1084.63000
PSA 408.72000
LogP 3.13620
Storage condition 2-8℃

 Synonyms

Aβ(30-40)
β-Amyloid (29-40)
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