AI-10-104
Modify Date: 2024-01-19 18:53:07
AI-10-104 structure
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Common Name | AI-10-104 | ||
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| CAS Number | 1881276-00-1 | Molecular Weight | 309.248 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H10F3N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AI-10-104AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays; reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells; impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM). |
| Name | AI-10-104 |
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| Description | AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays; reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells; impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM). |
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| References | References 1. Choi A, et al. Blood. 2017 Oct 12;130(15):1722-1733. 2. Illendula A, et al. EBioMedicine. 2016 Jun;8:117-31. View Related Products by Target RUNX1-CBFβ |
| Molecular Formula | C14H10F3N3O2 |
|---|---|
| Molecular Weight | 309.248 |