AI-3
Modify Date: 2023-01-16 17:25:43
AI-3 structure
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Common Name | AI-3 | ||
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| CAS Number | 882288-28-0 | Molecular Weight | 292.80200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H13ClO3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AI-3AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases[1]. |
| Name | Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl) |
|---|---|
| Synonym | More Synonyms |
| Description | AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases[1]. |
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| Related Catalog | |
| Target |
ARE[1] |
| In Vitro | AI-3 (0.1, 0.3, 1, 3.2, 10, 32 µM; 12, 24 h) 在 IMR-32 细胞中以剂量依赖方式增加 NQO1 的转录水平和蛋白质表达水平[1] . AI-3 (10 µM; 2-24 h) 诱导 GSH 合成从 4 小时开始到 24 小时[1]。 AI-3 在 IMR-32 细胞中的生物活性需要 Nrf2 和 PI3K的参与[1]。 Western Blot Analysis[1] Cell Line: IMR-32 cells Concentration: 0.1, 0.3, 1, 3.2, 10, 32 µM Incubation Time: 24 h Result: Induced NQO1 protein expression starting from 0.3 μM. |
| References |
| Molecular Formula | C11H13ClO3S2 |
|---|---|
| Molecular Weight | 292.80200 |
| Exact Mass | 291.99900 |
| PSA | 87.83000 |
| LogP | 4.04090 |
| L-368,899 hydrochloride |