EPZ028862

Modify Date: 2025-08-29 11:33:08

EPZ028862 Structure
EPZ028862 structure
 Common Name EPZ028862
CAS Number 1887082-53-2 Molecular Weight 422.54
Density N/A Boiling Point N/A
Molecular Formula C20H30N4O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EPZ028862


EPZ028862 is a selective SMYD3 inhibitor for cancer research[1].

 Names

Name EPZ028862

 EPZ028862 Biological Activity

Description EPZ028862 is a selective SMYD3 inhibitor for cancer research[1].
Related Catalog
In Vivo The pharmacokinetic parameters of EPZ028862( IV: 1 mg/kg; PO: 5 mg/kg) Parameter Mouse Rat Dog Cynomolgus CLp(mL/min/kg) 79.8 32.7 13.9 21.4 CLr(mL/min/kg) 23.6 21 1.97 1.06 Vss(L/kg) 9.5 4.4 5.8 9.5 t1/2(h) 2 2.1 5.4 5.6 MRT(h) 2 59 7 7.4 tmax(h) 0.33 1 1.5 2 F(%) 100 59 70 62
References

[1]. Michael J Thomenius, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS One. 2018 Jun 1;13(6):e0197372.  

 Chemical & Physical Properties

Molecular Formula C20H30N4O4S
Molecular Weight 422.54
InChIKey JYZQPJRVTADXNE-MSJJKYGJSA-N
SMILES NC1CCC(S(=O)(=O)N2C3CCC2CC(NC(=O)c2cc(C4CC4)on2)C3)CC1
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Chemsrc provides EPZ028862(CAS#:1887082-53-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of EPZ028862 are included as well.>> amp version: EPZ028862

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