DMA structure
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Common Name | DMA | ||
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CAS Number | 188860-26-6 | Molecular Weight | 468.55000 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C27H28N6O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of DMADMA is a fluorescent compound (λex=340 nm, λem=478 nm). |
Name | 2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole |
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Synonym | More Synonyms |
Description | DMA is a fluorescent compound (λex=340 nm, λem=478 nm). |
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Related Catalog | |
Target |
IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)[1] |
In Vitro | The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC50 is observed at 5.3 μM for DMA. The IC50 determined in the case of HeLa is 3.4 μM for DMA[1]. |
Cell Assay | Various human tumor cells (U87, HeLa and MCF7) are maintained as monolayer at 37°C in 5% CO2 using DMEM medium. Approximately 3000-8000 cells/well are seeded in 96-well plates containing 200 μL of medium and incubated for 24 h. The culture medium is replaced by fresh medium containing 1, 10, 50, 100 μM of DMA (6c) and incubated for 24, 48 and 72 h. The cell viability is determined by the MTT assay. The light absorbance is measured using a microplate reader[1]. |
References |
Molecular Formula | C27H28N6O2 |
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Molecular Weight | 468.55000 |
Exact Mass | 468.22700 |
PSA | 82.30000 |
LogP | 4.54510 |
Storage condition | 2-8℃ |
~60% DMA CAS#:188860-26-6 |
Literature: Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669 |
~% DMA CAS#:188860-26-6 |
Literature: Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669 |
~% DMA CAS#:188860-26-6 |
Literature: Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669 |
~% DMA CAS#:188860-26-6 |
Literature: Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669 |
~% DMA CAS#:188860-26-6 |
Literature: Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669 |
~% DMA CAS#:188860-26-6 |
Literature: Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669 |
~% DMA CAS#:188860-26-6 |
Literature: Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669 |
dma| |
cs-1309 |
DMA |