DMA

Modify Date: 2024-01-02 11:09:14

DMA Structure
DMA structure
Common Name DMA
CAS Number 188860-26-6 Molecular Weight 468.55000
Density N/A Boiling Point N/A
Molecular Formula C27H28N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DMA


DMA is a fluorescent compound (λex=340 nm, λem=478 nm).

 Names

Name 2-(3,4-dimethoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole
Synonym More Synonyms

 DMA Biological Activity

Description DMA is a fluorescent compound (λex=340 nm, λem=478 nm).
Related Catalog
Target

IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)[1]

In Vitro The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC50 is observed at 5.3 μM for DMA. The IC50 determined in the case of HeLa is 3.4 μM for DMA[1].
Cell Assay Various human tumor cells (U87, HeLa and MCF7) are maintained as monolayer at 37°C in 5% CO2 using DMEM medium. Approximately 3000-8000 cells/well are seeded in 96-well plates containing 200 μL of medium and incubated for 24 h. The culture medium is replaced by fresh medium containing 1, 10, 50, 100 μM of DMA (6c) and incubated for 24, 48 and 72 h. The cell viability is determined by the MTT assay. The light absorbance is measured using a microplate reader[1].
References

[1]. Singh M, et al. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles. Eur J Med Chem. 2011 Feb;46(2):659-69.

 Chemical & Physical Properties

Molecular Formula C27H28N6O2
Molecular Weight 468.55000
Exact Mass 468.22700
PSA 82.30000
LogP 4.54510
Storage condition 2-8℃

 Synonyms

dma|
cs-1309
DMA