NGB 2904 hydrochloride
Modify Date: 2025-08-25 09:48:50
NGB 2904 hydrochloride structure
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Common Name | NGB 2904 hydrochloride | ||
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| CAS Number | 189061-11-8 | Molecular Weight | 530.916 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H30Cl3N3O | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of NGB 2904 hydrochlorideNGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine-induced reinstatement of drug-seeking behavior[1][2]. |
| Name | NGB 2904 |
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| Synonym | More Synonyms |
| Description | NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine-induced reinstatement of drug-seeking behavior[1][2]. |
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| Related Catalog | |
| Target |
D3 Receptor:1.4 (Ki) |
| In Vitro | NGB 2904 antagonizes Quinpirole (100 nM)-stimulated mitogenesis, with an IC50 of 5.0 nM[1]. |
| In Vivo | NGB 2904 (0.1-5 mg/kg; i.p. 30 min prior to test) attenuates Cocaine's rewarding effects as assessed by PR self-administration, BSR, and Cocaine-triggered reinstatement of Cocaine-seeking behavior in rats[2]. NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice[3]. NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice[3]. Animal Model: Naïve male Long-Evans rats (250-300g)[2] Dosage: 0.1, 1, 5 mg/kg Administration: I.p. 30 min prior to test Result: Lowered the break-point for Cocaine (0.5 mg/kg; infusion) self-administration under progressive-ratio (PR) reinforcement. Inhibited the Cocaine (2 mg/kg; i.p.)-enhanced electrical brain stimulation reward (BSR). Inhibited Cocaine (10 mg/kg; i.p.)-triggered reinstatement of extinguished drug-seeking behavior. |
| References |
| Molecular Formula | C28H30Cl3N3O |
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| Molecular Weight | 530.916 |
| Exact Mass | 529.145447 |
| InChIKey | PFIWYJNBKGCVFM-UHFFFAOYSA-N |
| SMILES | Cl.O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2 |
| RIDADR | NONH for all modes of transport |
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The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion.
Pharmacol. Biochem. Behav. 86(4) , 718-26, (2007) The dopamine D3 receptor is believed to play an important role in regulation of rodent locomotor behavior, and has been proposed as a therapeutic target for substance abuse, psychotic disorders, and P... |
| MFCD09971107 |
| N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-9H-fluorene-2-carboxamide hydrochloride (1:1) |
| N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride |
| NGB 2904 hydrochloride |
| 9H-Fluorene-2-carboxamide, N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-, hydrochloride (1:1) |
| NGB 2904 (hydrochloride) |
| N-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}-9H-fluorene-2-carboxamide hydrochloride (1:1) |