LONAFARNIB
Modify Date: 2025-09-12 05:44:15
LONAFARNIB structure
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Common Name | LONAFARNIB | ||
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| CAS Number | 193275-86-4 | Molecular Weight | 638.822 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 710.4±70.0 °C at 760 mmHg | |
| Molecular Formula | C27H31Br2ClN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 383.5±35.7 °C | |
Use of LONAFARNIB(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1]. |
| Name | 4-{2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl}-1-piperidinecarboxamide |
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| Synonym | More Synonyms |
| Description | (Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 710.4±70.0 °C at 760 mmHg |
| Molecular Formula | C27H31Br2ClN4O2 |
| Molecular Weight | 638.822 |
| Flash Point | 383.5±35.7 °C |
| Exact Mass | 636.050232 |
| LogP | 5.03 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.630 |
| 1-Piperidinecarboxamide, 4-[2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]- |
| 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide |
| 4-{2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl}-1-piperidinecarboxamide |
| MFCD06795138 |