Tartrazine

Modify Date: 2025-08-21 10:31:29

Tartrazine Structure
Tartrazine structure
Common Name Tartrazine
CAS Number 1934-21-0 Molecular Weight 534.36
Density 1.93 g/cm3 (20ºC) Boiling Point N/A
Molecular Formula C16H9N4Na3O9S2 Melting Point 300ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08
Signal Word Danger

 Use of Tartrazine


Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring. Tartrazine is water-soluble and has a maximum absorbance in an aqueous solution at 425 nm.

 Names

Name tartrazine
Synonym More Synonyms

 Tartrazine Biological Activity

Description Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring. Tartrazine is water-soluble and has a maximum absorbance in an aqueous solution at 425 nm.
Related Catalog

 Chemical & Physical Properties

Density 1.93 g/cm3 (20ºC)
Melting Point 300ºC
Molecular Formula C16H9N4Na3O9S2
Molecular Weight 534.36
PSA 220.19000
LogP 2.78190
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ6400000
CHEMICAL NAME :
Pyrazole-3-carboxylic acid, 5-hydroxy-1-(p-sulfophenyl)-4-(p-sulfophenyl)azo-, trisodium salt
CAS REGISTRY NUMBER :
1934-21-0
LAST UPDATED :
199710
DATA ITEMS CITED :
23
MOLECULAR FORMULA :
C16-H9-N4-O9-S2.3Na
MOLECULAR WEIGHT :
534.38
WISWESSER LINE NOTATION :
T5NNJ AR DSWO& CVO DNUNR DSWO& EQ &-NA- 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
14 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Musculoskeletal - changes in teeth and supporting structures
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
476 mg/kg/28D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
18500 mg/kg
SEX/DURATION :
female 7-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1280 mg/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20 gm/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
Specific locus test

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Mammal - species unspecified Fibroblast
DOSE/DURATION :
5 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,461,1982 *** REVIEWS *** TOXICOLOGY REVIEW DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 9,198,1975 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2148 No. of Facilities: 2666 (estimated) No. of Industries: 32 No. of Occupations: 45 No. of Employees: 47875 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2148 No. of Facilities: 15429 (estimated) No. of Industries: 95 No. of Occupations: 99 No. of Employees: 318163 (estimated) No. of Female Employees: 157622 (estimated)

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H317-H334
Precautionary Statements P261-P280-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn
Risk Phrases R42/43
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS UQ6400000

 Precursor & DownStream

Precursor  0

DownStream  1

 Articles31

More Articles
Toxic effects of some synthetic food colorants and/or flavor additives on male rats.

Toxicol. Ind. Health 29(2) , 224-32, (2013)

The objective of the present work was to evaluate the broadest toxic effect of some synthetic additives of colorants and/or flavors on different body organs and metabolic aspects in rats. A number of ...

Pattern of intake of food additives associated with hyperactivity in Irish children and teenagers.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 27(4) , 447-56, (2010)

A double-blind randomized intervention study has previously shown that a significant relationship exists between the consumption of various mixes of seven target additives by children and the onset of...

Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive manner.

J. Environ. Public Health 2009 , 953952, (2009)

The synthetic food dyes studied were rose bengal (RB), phroxine (PL), amaranth, erythrosine B (ET), allura red, new coccine, acid red (AR), tartrazine, sunset yellow FCF, brilliant blue FCF, and indig...

 Synonyms

Trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(E)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1H-pyrazole-3-carboxylate
1310yellow
c.i.640
1H-Pyrazole-3-carboxylic acid, 2,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(E)-2-(4-sulfophenyl)diazenyl]-, sodium salt (1:3)
EINECS 217-699-5
1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-, trisodium salt
C16H9N4Na3O9S2
YELLOW 5
Tartrazin
TARTRAZINE
FD & C Yellow 5
y-4
3-carboxy-5-hydroxy-1-para-sulfophenyl-4-para-sulfophenylazopyrazole trisodium salt
FD & C Yellow No. 5
Food Yellow No. 4
TARTAZINE
tartarazine
E102
MFCD00148908
FD and C Yellow No. 5
Acid Yellow 23
1H-pyrazole-3-carboxylic acid, 2,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(E)-(4-sulfophenyl)azo]-, trisodium salt
l-gelb2
Filter Yellow
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