AV-153 free base

Modify Date: 2024-01-02 11:46:40

AV-153 free base structure	Common Name	AV-153 free base
	CAS Number	19350-66-4	Molecular Weight	297.30400
	Density	1.23g/cm3	Boiling Point	450.5ºC at 760mmHg
	Molecular Formula	C₁₄H₁₉NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	226.3ºC

Use of AV-153 free base

AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity[1][2][3].

Name	3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid
Synonym	More Synonyms

Description	AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	AV-153 free base causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively[1]. AV-153 free base (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13–67%[1].
References	[1]. Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells in Vitro. Mutat Res. 2005 Nov 10;587(1-2):52-8. [2]. E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. Chem Biol Interact. 2014 Sep 5;220:200-7. [3]. Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro. Antioxidants (Basel). 2018 Sep 19;7(9):123.

Density	1.23g/cm3
Boiling Point	450.5ºC at 760mmHg
Molecular Formula	C₁₄H₁₉NO₆
Molecular Weight	297.30400
Flash Point	226.3ºC
Exact Mass	297.12100
PSA	101.93000
LogP	1.29340
Vapour Pressure	2.26E-09mmHg at 25°C
Index of Refraction	1.51

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester

2.6-dimethyl-3,5-diethoxycarbonyl-1-4-dihydroisonicotinic acid

3,5-Diethoxycarbonyl-2,6-dimethyl-1,4-dihydroisonicotinsaeure

2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydro-pyridin-4-carbonsaeure

3,4,5-pyridinetricarboxylic acid,1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester

2,5-DIISOPROPYLPHENOL

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: AV-153 free base
Price: ￥11746.0/5g ￥4046.0/1g ￥1616.0/250mg ￥1016.0/100mg
Purity: 97.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: AV-153 free base
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥1100/10 mM * 1 mL in DMSO

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AV-153 free base

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