AV-153
Modify Date: 2024-02-04 20:30:30
AV-153 structure
|
Common Name | AV-153 | ||
|---|---|---|---|---|
| CAS Number | 27296-05-5 | Molecular Weight | 319.28600 | |
| Density | N/A | Boiling Point | 450.5ºC at 760mmHg | |
| Molecular Formula | C14H18NNaO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AV-153AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity[1][2][3]. |
| Name | sodium,3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate |
|---|
| Description | AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | AV-153 causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively[1]. AV-153 (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13-67%[1]. |
| References |
| Boiling Point | 450.5ºC at 760mmHg |
|---|---|
| Molecular Formula | C14H18NNaO6 |
| Molecular Weight | 319.28600 |
| Exact Mass | 319.10300 |
| PSA | 104.76000 |
| Vapour Pressure | 2.26E-09mmHg at 25°C |