C.I. Direct Black 38

Modify Date: 2025-08-22 15:48:39

C.I. Direct Black 38 Structure
C.I. Direct Black 38 structure
 Common Name C.I. Direct Black 38
CAS Number 1937-37-7 Molecular Weight 781.728
Density 1.61g/cm3 Boiling Point N/A
Molecular Formula C34H25N9Na2O7S2 Melting Point 109-110°C
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Danger

 Use of C.I. Direct Black 38


Direct Black 38 is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].

 Names

Name Direct Black 38
Synonym More Synonyms

 C.I. Direct Black 38 Biological Activity

Description Direct Black 38 is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].
Related Catalog
References

[1]. Beije B. Induction of unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats exposed in vivo to the benzidine-derived azo dye, Direct Black 38. Mutat Res. 1987 Apr;187(4):227-34.

 Chemical & Physical Properties

Density 1.61g/cm3
Melting Point 109-110°C
Molecular Formula C34H25N9Na2O7S2
Molecular Weight 781.728
Exact Mass 781.111389
PSA 303.61000
LogP 11.91860
Index of Refraction 1.768

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ6160000
CHEMICAL NAME :
2,7-Naphthalenedisulfonic acid, 4-amino-3-((4'-((2,4-diaminophenyl)azo)(1,1'-biphenyl )-4-yl) azo)-5-hydroxy-6-(phenylazo)-, disodium salt
CAS REGISTRY NUMBER :
1937-37-7
LAST UPDATED :
199801
DATA ITEMS CITED :
32
MOLECULAR FORMULA :
C34-H25-N9-O7-S2.2Na
MOLECULAR WEIGHT :
781.78
WISWESSER LINE NOTATION :
L66J BZ CNUNR DR DNUNR DR DNUNR BZ DZ&&& DSWO HSWO INUNR JQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 gm/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1262 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6825 mg/kg/13W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
34 mg/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13286 mg/kg/13W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
Body fluid assay
TEST SYSTEM :
Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION :
300 mg/kg
REFERENCE :
IAEHDW International Archives of Occupational and Environmental Health. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.35- 1975- Volume(issue)/page/year: 49,177,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,295,1982 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,295,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1410 No. of Facilities: 704 (estimated) No. of Industries: 10 No. of Occupations: 27 No. of Employees: 16432 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1410 No. of Facilities: 298 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 11374 (estimated) No. of Female Employees: 5821 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H319-H350-H361d
Precautionary Statements P201-P280-P305 + P351 + P338-P308 + P313
Personal Protective Equipment Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R45;R63
Safety Phrases S53-S45
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS QJ6160000

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 Synonyms

AZO BLACK
Chlorazol Black E
MFCD00066363
Chlorazol Black E,certified
2,7-Naphthalenedisulfonic acid, 4-amino-3-[(E)-2-[4'-[(E)-2-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl]diazenyl]-5-hydroxy-6-[(E)-2-phenyldiazenyl]-, sodium salt (1:2)
C.I. Direct Black 38
Chlorazol Black
metablack
erieblackb
ERIE BLACK
2,7-naphthalenedisulfonic acid, 4-amino-3-[(E)-[4'-[(E)-(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-[(E)-phenylazo]-, disodium salt
black2embl
EINECS 217-710-3
Disodium 4-amino-3-[(E)-{4'-[(E)-(2,4-diaminophenyl)diazenyl]-4-biphenylyl}diazenyl]-5-hydroxy-6-[(E)-phenyldiazenyl]-2,7-naphthalenedisulfonate
black4embl
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Related Compounds: More...
2-Naphthalenesulfonic acid, 3-[2-[4-[2-(2,4-diaminophenyl)diazenyl]phenyl]diazenyl]-6-[2-(2,4-diamino-5-sulfophenyl)diazenyl]-4-hydroxy-, disodium salt
83293-51-0
C.I. Direct black 146
12221-96-4
C.I. Direct Black 17
2945-96-2
Rayon Black R
6745-67-1
Direct Black 168
85631-88-5
2,7-Naphthalenedisulfonicacid,4-amino-3-[2-[4'-[2-(1-amino-5-sulfo-2-naphthalenyl)diazenyl][1,1'-biphenyl]-4-yl]diazenyl]-5-hydroxy-6-(2-phenyldiazenyl)-,sodium salt (1:3)
6486-54-0
DIRECT BLACK 38
381937-37-7
C.I. Direct Green 38, trisodium salt
5893-32-3
C.I. Reactive blue 38
12236-90-7
Ethylthionitazene
102758-70-3
E9SX7D5Pwm
114720-02-4
Etravirine impurity 6
1704730-70-0
Propylnitrolic acid
10565-53-4
Stavudine glucuronide, (C14)-
1297329-88-4
4-(2,6-Difluoro-4-methylphenyl)-2-methylbutan-2-amine
2229608-43-7
9-Hydroxycorynantheidine sulfate ester
1622324-56-4
Suffrupaeonidanin E
1528763-66-7
Methyl 16-(3-pyridinoylhydrazono)-ent-beyeran-19-oate
1334421-51-0
GQ7Tll8jjm
72363-33-8
Chemsrc provides C.I. Direct Black 38(CAS#:1937-37-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of C.I. Direct Black 38 are included as well.>> amp version: C.I. Direct Black 38

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