Nitro-PDS-Tubulysin M
Modify Date: 2024-01-10 18:19:35
Nitro-PDS-Tubulysin M structure
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Common Name | Nitro-PDS-Tubulysin M | ||
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| CAS Number | 1941168-69-9 | Molecular Weight | 1106.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C54H73N8O11S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nitro-PDS-Tubulysin MNitro-PDS-Tubulysin M has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. Nitro-PDS-Tubulysin M is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2]. |
| Name | Nitro-PDS-Tubulysin M |
|---|
| Description | Nitro-PDS-Tubulysin M has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. Nitro-PDS-Tubulysin M is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2]. |
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| Related Catalog | |
| In Vitro | ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.147 nM, and ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC50s of 2.07 nM, 1.004 nM, respectively[1]. |
| References |
| Molecular Formula | C54H73N8O11S3 |
|---|---|
| Molecular Weight | 1106.40 |