2-O-Acetyl-20-hydroxyecdysone

Modify Date: 2024-01-10 08:44:11

2-O-Acetyl-20-hydroxyecdysone Structure
2-O-Acetyl-20-hydroxyecdysone structure
Common Name 2-O-Acetyl-20-hydroxyecdysone
CAS Number 19536-25-5 Molecular Weight 522.67
Density 1.26±0.1 g/cm3 Boiling Point 707.3±60.0 °C
Molecular Formula C29H46O8 Melting Point 218-220 ºC
MSDS N/A Flash Point N/A

 Use of 2-O-Acetyl-20-hydroxyecdysone


2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β42 (Aβ42)-induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils[1].

 Names

Name 20-hydroxyecdysone, 2-acetate
Synonym More Synonyms

 2-O-Acetyl-20-hydroxyecdysone Biological Activity

Description 2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β42 (Aβ42)-induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils[1].
Related Catalog
References

[1]. Yang SG, et al. Diverse ecdysterones show different effects on amyloid-β42 aggregation but all uniformly inhibit amyloid-β42-induced cytotoxicity. J Alzheimers Dis. 2010;22(1):107-17.

 Chemical & Physical Properties

Density 1.26±0.1 g/cm3
Boiling Point 707.3±60.0 °C
Melting Point 218-220 ºC
Molecular Formula C29H46O8
Molecular Weight 522.67
Exact Mass 522.319
PSA 144.52
LogP 2.4248
Water Solubility Very slightly soluble (0.24 g/L) (25 ºC)

 Safety Information

Hazard Codes Xi

 Synonyms

β-Ecdysone 2-acetate
2-O-Acetyl-20-hydroxyecdysone