GAP 26 trifluoroacetate salt

Modify Date: 2025-08-25 18:17:58

GAP 26 trifluoroacetate salt Structure
GAP 26 trifluoroacetate salt structure
Common Name GAP 26 trifluoroacetate salt
CAS Number 197250-15-0 Molecular Weight 1550.78
Density N/A Boiling Point N/A
Molecular Formula C70H106N19O19S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GAP 26 trifluoroacetate salt


Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

 Names

Name Gap 26
Synonym More Synonyms

 GAP 26 trifluoroacetate salt Biological Activity

Description Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
Related Catalog
Target

Gap Junction Protein[1]

In Vitro Gap 26 is corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[1]. Gap 26 abolishes the inositol-1,4,5-trisphosphate (InsP3)-triggered ATP response and reduces the ATP release, but has no effect on gap junctional coupling[2].
References

[1]. Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110.

[2]. Braet K, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.

 Chemical & Physical Properties

Molecular Formula C70H106N19O19S
Molecular Weight 1550.78
PSA 657.12000
LogP 1.84770
Storage condition 2-8℃

 Synonyms

Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
M.W. 1550.78 C70H107N19O19S
VCYDKSFPISHVR
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