Sulfamethazine sodium salt

Modify Date: 2024-01-02 21:24:03

Sulfamethazine sodium salt structure	Common Name	Sulfamethazine sodium salt
	CAS Number	1981-58-4	Molecular Weight	300.312
	Density	1.392g/cm3	Boiling Point	526.2ºC at 760mmHg
	Molecular Formula	C₁₂H₁₃N₄NaO₂S	Melting Point	176ºC
	MSDS	Chinese USA	Flash Point	272.1ºC
	Symbol	GHS07	Signal Word	Warning

Use of Sulfamethazine sodium salt

Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg[1][2].

Name	sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide
Synonym	More Synonyms

Description	Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Bacterial[1]
In Vivo	Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1]. Animal Model: 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1] Dosage: 80 mg/kg Administration: Intravenous injection (Pharmacokinetic study) Result: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.
References	[1]. VAN Poucke LSG, et al. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994 Sep;57(9):796-801. [2]. Sheng Y J, et al. Production of chicken yolk IgY to sulfamethazine: comparison with rabbit antiserum IgG. Food and Agricultural Immunology. 2015, 26(3):305-316.

Density	1.392g/cm3
Boiling Point	526.2ºC at 760mmHg
Melting Point	176ºC
Molecular Formula	C₁₂H₁₃N₄NaO₂S
Molecular Weight	300.312
Flash Point	272.1ºC
Exact Mass	300.065704
PSA	97.56000
LogP	2.99720
Appearance of Characters	white to off-white
Vapour Pressure	3.64E-11mmHg at 25°C
Storage condition	2-8°C
Water Solubility	H2O: soluble50mg/mL

Sulfamethazine sodium salt MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9300000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt

CAS REGISTRY NUMBER :: 1981-58-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H14-N4-O2-S.Na

MOLECULAR WEIGHT :: 301.35

WISWESSER LINE NOTATION :: T6NJ CNJ BMR D2SZW &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 974 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 699 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 605 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 52,1789,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4891 No. of Facilities: 299 (estimated) No. of Industries: 2 No. of Occupations: 18 No. of Employees: 3501 (estimated) No. of Female Employees: 883 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	WO9300000
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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Depletion kinetics of 14C-sulfamethazine [4-amino-N-(4, 6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] metabolism in swine.

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MFCD00068333

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sulfamethazine sodium salt
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China
Product Name: Sulfamethazine sodium salt
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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