Sulfamethazine sodium salt
Sulfamethazine sodium salt structure
|
Common Name | Sulfamethazine sodium salt | ||
|---|---|---|---|---|
| CAS Number | 1981-58-4 | Molecular Weight | 300.312 | |
| Density | 1.392g/cm3 | Boiling Point | 526.2ºC at 760mmHg | |
| Molecular Formula | C12H13N4NaO2S | Melting Point | 176ºC | |
| MSDS | Chinese USA | Flash Point | 272.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Sulfamethazine sodium saltSulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Bacterial[1] |
| In Vivo | Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1]. Animal Model: 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1] Dosage: 80 mg/kg Administration: Intravenous injection (Pharmacokinetic study) Result: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.392g/cm3 |
|---|---|
| Boiling Point | 526.2ºC at 760mmHg |
| Melting Point | 176ºC |
| Molecular Formula | C12H13N4NaO2S |
| Molecular Weight | 300.312 |
| Flash Point | 272.1ºC |
| Exact Mass | 300.065704 |
| PSA | 97.56000 |
| LogP | 2.99720 |
| Appearance of Characters | white to off-white |
| Vapour Pressure | 3.64E-11mmHg at 25°C |
| InChIKey | NGIVTUVVBWOTNT-UHFFFAOYSA-N |
| SMILES | Cc1cc(C)nc([N-]S(=O)(=O)c2ccc(N)cc2)n1.[Na+] |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble50mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | WO9300000 |
| HS Code | 2935009090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.
Sci. Total Environ. 511 , 153-60, (2015) The development, characterisation and application of a new analytical method for multi-residue PPCP determination in the freshwater amphipod, Gammarus pulex are presented. Analysis was performed using... |
|
|
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.
Nucleic Acids Res. 39 , D1035-41., (2011) DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, ... |
|
|
Depletion kinetics of 14C-sulfamethazine [4-amino-N-(4, 6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] metabolism in swine.
Drug Metab. Dispos. 14 , 161, (1986) Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
|
|
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
|
|
Name: Absorbance-based primary biochemical high throughput screening assay to identify acti...
Source: The Scripps Research Institute Molecular Screening Center
Target: caspase-3 preproprotein [Homo sapiens]
External Id: PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MFCD00068333 |
| Sodium sulfametazine |
| Sodium sulfamezathine |
| Bovibol |
| 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide |
| Sodium [(4-aminophenyl)sulfonyl](4,6-dimethylpyrimidin-2-yl)azanide |
| sulfamethazine sodium |
| 4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide Sodium Salt |
| Sodium sulfamethiazine |
| sodium sulfamethazine |
| Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, sodium salt (1:1) |
| Sulfadimidine sodium |
| Sodium [(4-aminophenyl)sulfonyl](4,6-dimethyl-2-pyrimidinyl)azanide |
| sodium sulfadimidinato |
| sulphadimidine sodium |
| Sodium sulfamethamide |
| sulfamethazine sodium salt |
| Sodium sulphamezathine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: How is the water solubility of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: Water solubility of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide: H2O: soluble50mg/mL. |
| Q: What is the safety information for sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: Safety information for sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide: S36. |
| Q: What is the English name of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: The English name of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide is sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide. |
| Q: What are the uses of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: Main uses of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide: Sulfamethazine sodium (Sulfadimidine sodium) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine sodium in animal product is set at 100 µg/kg[1][2]. |
| Q: What is the SMILES notation of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: SMILES notation of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide is Cc1cc(C)nc([N-]S(=O)(=O)c2ccc(N)cc2)n1.[Na+]. |
| Q: What is the molecular formula of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: Molecular formula of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide is C12H13N4NaO2S. |
| Q: What is the boiling point of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: Boiling point of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide is 526.2ºC at 760mmHg. |
| Q: What is the polar surface area (PSA) of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: Polar surface area (PSA) of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide is 97.56000. |
| Q: What is the physical appearance of sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide appears as white to off-white. |
| Q: What are the storage conditions for sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide? |
| A: Storage conditions for sodium,(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide: 2-8°C. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |