Parecoxib sodiuM

Modify Date: 2025-08-20 22:37:13

Parecoxib sodiuM Structure
Parecoxib sodiuM structure
 Common Name Parecoxib sodiuM
CAS Number 198470-85-8 Molecular Weight 392.404
Density N/A Boiling Point 538ºC at 760mmHg
Molecular Formula C19H17N2NaO4S Melting Point 273-275°C
MSDS N/A Flash Point 279.2ºC

 Use of Parecoxib sodiuM


Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].

 Names

Name Parecoxib sodium
Synonym More Synonyms

 Parecoxib sodiuM Biological Activity

Description Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].
Related Catalog
Target

COX-2

References

[1]. Schreder H, et al. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. Neurochem Int. 2011 Jan;58(1):9-13.

[2]. Ye Z, et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochem Res. 2012 Feb;37(2):321-9.

[3]. Guo YJ, et al. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp Ther Med. 2013 Jul;6(1):275-279.

 Chemical & Physical Properties

Boiling Point 538ºC at 760mmHg
Melting Point 273-275°C
Molecular Formula C19H17N2NaO4S
Molecular Weight 392.404
Flash Point 279.2ºC
Exact Mass 392.080658
PSA 85.62000
LogP 5.39680
Storage condition Refrigerator

 Synonyms

Rayzon
Parecoxib sodiuM salt
Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodium salt (1:1)
N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt
Sodium {[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}(propionyl)azanide
N-[[p-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propionamide Sodium Salt
Parecoxib (Sodium)
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