Bersanlimab

Modify Date: 2024-02-06 10:04:36

Bersanlimab Structure
Bersanlimab structure
Common Name Bersanlimab
CAS Number 1987854-08-9 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bersanlimab


Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects[1].

 Names

Name Bersanlimab

 Bersanlimab Biological Activity

Description Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects[1].
Related Catalog
In Vitro BI-505(1 ng/mL-1000 μg/mL)剂量依赖性地诱导表达 ICAM-1 的 Ramos、Raji 和 Daudi 淋巴瘤细胞的程序性细胞死亡 (PCD)[1]。
In Vivo Bersanlimab(BI-505;20 mg/kg;腹腔注射;每周两次;持续 21 天)显着减少肿瘤生长并延长动物存活期[1]。 Animal Model: SCID mice injected with ARH-77 cells[1] Dosage: 20 mg/kg Administration: i.p.; twice-weekly; for 21 days Result: Significantly reduced tumor growth and prolonged animal survival.
References

[1]. Niina Veitonmäki, et al. A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell. 2013 Apr 15;23(4):502-15.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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