T 98475

Modify Date: 2024-01-18 10:49:50

T 98475 Structure
T 98475 structure
Common Name T 98475
CAS Number 199119-18-1 Molecular Weight 657.77
Density N/A Boiling Point N/A
Molecular Formula C37H37F2N3O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of T 98475


T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].

 Names

Name Isopropyl 3-{[benzyl(methyl)amino]methyl}-7-(2,6-difluorobenzyl)- 2-[4-(isobutyrylamino)phenyl]-4-oxo-4,7-dihydrothieno[2,3-b]pyrid ine-5-carboxylate

 T 98475 Biological Activity

Description T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].
Related Catalog
Target

IC50: 0.2 nM (human LHRH receptor), 2 nM (monkey LHRH receptor), 4 nM (monkey anterior pituitaries), 60 nM (rat anterior pituitaries)[1]

References

[1]. Imada T, et al. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3809-25.

 Chemical & Physical Properties

Molecular Formula C37H37F2N3O4S
Molecular Weight 657.77
Exact Mass 657.24700
PSA 108.88000
LogP 7.92120
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