T-521
Modify Date: 2024-01-11 15:27:36
T-521 structure
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Common Name | T-521 | ||
|---|---|---|---|---|
| CAS Number | 891020-54-5 | Molecular Weight | 395.425 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 637.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C26H27Cl2N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 339.2±34.3 °C | |
Use of T-521T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3; impedes the interaction between Plk1 and Bub1, exhibits dramatic mitotic defects in HeLa cells; suppresses the growth of A549 cells in xenograft nude mice. |
| Name | 5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole |
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| Synonym | More Synonyms |
| Description | T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3; impedes the interaction between Plk1 and Bub1, exhibits dramatic mitotic defects in HeLa cells; suppresses the growth of A549 cells in xenograft nude mice. |
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| References | References 1. Chen Y, et al. Oncotarget. 2017 Jan 3;8(1):1234-1246. View Related Products by Target Polo-like Kinase (PLK) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 637.2±65.0 °C at 760 mmHg |
| Molecular Formula | C26H27Cl2N5O2 |
| Molecular Weight | 395.425 |
| Flash Point | 339.2±34.3 °C |
| Exact Mass | 395.029755 |
| LogP | 3.08 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.578 |
| 5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole |
| Oxazole, 5-(ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)- |