NNC 26-9100

• 常用名: NNC 26-9100
• 英文名: NNC 26-9100
• CAS号: 199522-35-5
• 分子量: 556.35
• 密度: 1.482g/cm3
• 沸点: 731.167ºC at 760 mmHg
• 分子式: C₂₂H₂₅BrCl₂N₆S
• 熔点: N/A
• 闪点: 395.996ºC

NNC 26-9100用途

NNC 26-9100 是一种选择性的生长抑素 sst4 受体完全激动剂 (Ki: 6 nM, EC50：2 nM)。NNC 26-9100 降低总的可溶性 Aβ42,增加脑啡肽酶活性并改善学习能力。

NNC 26-9100名称

• 英文名: NNC 26-9100,1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea

NNC 26-9100生物活性

• 描述: NNC 26-9100 是一种选择性的生长抑素 sst4 受体完全激动剂 (Ki: 6 nM, EC50：2 nM)。NNC 26-9100 降低总的可溶性 Aβ42,增加脑啡肽酶活性并改善学习能力。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 生长抑素受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Michael Ankersen, et al. Discovery of a Novel Non-Peptide Somatostatin Agonist with SST4 Selectivity. J. Am. Chem. Soc. 1998, 120, 7, 1368-1373.

  [2]. Sandoval KE, et al. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain Res. 2013 Jul 3;1520:145-56.

NNC 26-9100物理化学性质

• 密度: 1.482g/cm3
• 沸点: 731.167ºC at 760 mmHg
• 分子式: C₂₂H₂₅BrCl₂N₆S
• 分子量: 556.35
• 闪点: 395.996ºC
• 精确质量: 554.04200
• PSA: 100.96000
• LogP: 6.14940
• InChIKey: UREJDUPKGMFJRU-UHFFFAOYSA-N
• SMILES: S=C(NCCCc1cnc[nH]1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.668

NNC 26-9100靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: S229-K512 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL5060751

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Thermal Shift Assay. Domain: start/stop: M1-K294 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL5063818

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Incucyte cell viability with HEK293T 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL5058565

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：PDSP Secondary Binding target: ADRA2B - Compounds are tested at 10 uM concentration, ... 来源：ChEMBL 靶标：Alpha-2B adrenergic receptor External Id：CHEMBL5442195

实验名称：Thermal Shift Assay. Domain: start/stop: G861-E979 来源：ChEMBL 靶标：Transcription intermediary factor 1-alpha External Id：CHEMBL5068463

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NNC 26-9100英文别名

• Pam3CSK4 Biotin