7-Cyano-7-deaza-2'-deoxy guanosine

Modify Date: 2024-01-11 17:08:40

7-Cyano-7-deaza-2'-deoxy guanosine Structure
7-Cyano-7-deaza-2'-deoxy guanosine structure
Common Name 7-Cyano-7-deaza-2'-deoxy guanosine
CAS Number 199859-58-0 Molecular Weight 291.263
Density 1.9±0.1 g/cm3 Boiling Point N/A
Molecular Formula C12H13N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 7-Cyano-7-deaza-2'-deoxy guanosine


7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

 Names

Name 2-Amino-7-(2-deoxy-α-D-erythro-pentofuranosyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Synonym More Synonyms

 7-Cyano-7-deaza-2'-deoxy guanosine Biological Activity

Description 7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog
References

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Molecular Formula C12H13N5O4
Molecular Weight 291.263
Exact Mass 291.096741
LogP -1.91
Index of Refraction 1.849

 Synonyms

3H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 2-amino-7-(2-deoxy-α-D-erythro-pentofuranosyl)-4,7-dihydro-4-oxo-
2-Amino-7-(2-deoxy-α-D-erythro-pentofuranosyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile