ALX 5407 hydrochloride
Modify Date: 2025-08-25 11:43:11
ALX 5407 hydrochloride structure
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Common Name | ALX 5407 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 200006-08-2 | Molecular Weight | 429.91200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H25ClFNO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of ALX 5407 hydrochlorideALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1]. |
| Name | 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1]. |
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| Related Catalog | |
| In Vitro | ALX-5407 hydrochloride (0-1 mM) GlyT1- 或 GlyT2- 依赖地抑制甘氨酸转运，阻断大鼠大脑和 QT6-1C 细胞中 [3H] 甘氨酸的摄取，IC50 值为 3 nM[1]。 ALX-5407 hydrochloride (50 nM) 在 QT6-1C 细胞中表现出缓慢的解离动力学[1]。 |
| In Vivo | ALX-5407 hydrochloride (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平[1]。 |
| References |
| Molecular Formula | C24H25ClFNO3 |
|---|---|
| Molecular Weight | 429.91200 |
| Exact Mass | 429.15100 |
| PSA | 49.77000 |
| LogP | 5.82130 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H410 |
| Precautionary Statements | P273-P501 |
| Hazard Codes | Xi |
| RIDADR | UN 3077 9 / PGIII |
| N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine Hydrochloride |
| ALX 5407 hydrochloride |
| 187-1,N-WASP inhibitor |
| N-[3-(4'-Fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine hydrochloride |
| (+/-)-NFPS hydrochloride |