Triapine
Modify Date: 2025-09-10 22:54:15
Triapine structure
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Common Name | Triapine | ||
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| CAS Number | 200933-27-3 | Molecular Weight | 195.245 | |
| Density | 1.46 | Boiling Point | 436.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C7H9N5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 217.5±31.5 °C | |
Use of Triapine(E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2]. |
| Name | (2E)-2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide |
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| Synonym | More Synonyms |
| Description | (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2]. |
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| Related Catalog | |
| In Vitro | 3-AP shows anti-proliferative activity with IC50 values of 1.3, 1.6 µM for L1210, L1210/HUr cells, respectively[1]. 3-AP (5, 10, 15, 20, 30 mg/kg; i.p.; twice daily for six consecutive days) significantly increases in life span were observed with each dosage employed and long term survivors[1]. |
| References |
| Density | 1.46 |
|---|---|
| Boiling Point | 436.0±55.0 °C at 760 mmHg |
| Molecular Formula | C7H9N5S |
| Molecular Weight | 195.245 |
| Flash Point | 217.5±31.5 °C |
| Exact Mass | 195.057861 |
| PSA | 125.95000 |
| LogP | 0.98 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.720 |
| Storage condition | -20℃ |
| 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide |
| 2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide |
| Triapine |
| Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]- |
| 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide |