SB 243213 hydrochloride
Modify Date: 2024-02-01 14:39:29
SB 243213 hydrochloride structure
|
Common Name | SB 243213 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 200940-23-4 | Molecular Weight | 501.329 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20ClF3N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SB 243213 hydrochlorideSB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1]. |
| Name | 5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1]. |
|---|---|
| Target |
5-HT2C Receptor:9.37 (pKi) |
| In Vivo | SB-243213 hydrochloride is a potent inhibitor of central 5-HT2C receptor-mediated function in rats. SB-243213 hydrochloride exhibits anxiolytic-like activity in both the social interaction and Geller-Seifter conflict tests[1]. |
| References |
| Molecular Formula | C22H20ClF3N4O2 |
|---|---|
| Molecular Weight | 501.329 |
| Exact Mass | 500.099365 |
| PSA | 70.84000 |
| LogP | 5.57770 |
| 1H-Indole-1-carboxamide, 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-, hydrochloride (1:2) |
| 5-Methyl-N-{6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl}-6-(trifluoromethyl)-1-indolinecarboxamide dihydrochloride |
| Pazopanib + Tyverb/Tykerb |