200940-23-4

200940-23-4 structure

Name: SB 243213 hydrochloride
Chemical Name: 5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
CAS Number: 200940-23-4
Molecular Formula: C₂₂H₂₀ClF₃N₄O₂
Molecular Weight: 501.329
Create Date: 2016-08-28 21:43:35
Modify Date: 2024-02-01 14:39:29
SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1].

Name	5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
Synonyms	1H-Indole-1-carboxamide, 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-, hydrochloride (1:2) 5-Methyl-N-{6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl}-6-(trifluoromethyl)-1-indolinecarboxamide dihydrochloride Pazopanib + Tyverb/Tykerb

Description	SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1].
Target	5-HT2C Receptor:9.37 (pKi)
In Vivo	SB-243213 hydrochloride is a potent inhibitor of central 5-HT2C receptor-mediated function in rats. SB-243213 hydrochloride exhibits anxiolytic-like activity in both the social interaction and Geller-Seifter conflict tests[1].
References	[1]. Wood MD, et al. SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology. 2001 Aug;41(2):186-99.