Sivelestat Sodium tetrahydrate structure
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Common Name | Sivelestat Sodium tetrahydrate | ||
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CAS Number | 201677-61-4 | Molecular Weight | 528.506 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C20H29N2NaO11S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Sivelestat Sodium tetrahydrateSivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.IC50 value: 44 nM [1]Target: neutrophil elastaseONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2]. |
Name | sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate,tetrahydrate |
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Synonym | More Synonyms |
Description | Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.IC50 value: 44 nM [1]Target: neutrophil elastaseONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2]. |
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Related Catalog | |
References |
Molecular Formula | C20H29N2NaO11S |
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Molecular Weight | 528.506 |
Exact Mass | 528.138977 |
PSA | 187.00000 |
LogP | 2.20610 |
Storage condition | -20℃ |
Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt, hydrate (1:1:4) |
Sivelestat sodium hydrate |
Sivelestat Sodium |
Sivelestat sodium tetrahydrate |
Elaspol |
ONO-5046.Na |
(N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycinato-κO)sodium tetrahydrate |
Sodium ({2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}amino)acetate hydrate (1:1:4) |
sodium, [2,2-dimethylpropanoato, 4-[[[2-[[[(carboxy-κO)methyl]amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester]-, hydrate (1:4) |
MFCD01937969 |
UNII-737RR8Y409 |
Sivelestat (sodium tetrahydrate) |