Sivelestat Sodium tetrahydrate
Modify Date: 2025-08-26 17:00:58
Sivelestat Sodium tetrahydrate structure
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Common Name | Sivelestat Sodium tetrahydrate | ||
|---|---|---|---|---|
| CAS Number | 201677-61-4 | Molecular Weight | 528.506 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H29N2NaO11S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Sivelestat Sodium tetrahydrateSivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.IC50 value: 44 nM [1]Target: neutrophil elastaseONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2]. |
| Name | sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate,tetrahydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.IC50 value: 44 nM [1]Target: neutrophil elastaseONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2]. |
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| Related Catalog | |
| References |
| Molecular Formula | C20H29N2NaO11S |
|---|---|
| Molecular Weight | 528.506 |
| Exact Mass | 528.138977 |
| PSA | 187.00000 |
| LogP | 2.20610 |
| Storage condition | -20℃ |
| Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt, hydrate (1:1:4) |
| Sivelestat sodium hydrate |
| Sivelestat Sodium |
| Sivelestat sodium tetrahydrate |
| Elaspol |
| ONO-5046.Na |
| (N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycinato-κO)sodium tetrahydrate |
| Sodium ({2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}amino)acetate hydrate (1:1:4) |
| sodium, [2,2-dimethylpropanoato, 4-[[[2-[[[(carboxy-κO)methyl]amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester]-, hydrate (1:4) |
| MFCD01937969 |
| UNII-737RR8Y409 |
| Sivelestat (sodium tetrahydrate) |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Sivelestat Sodium tetrahydrate
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Sivelestat Sodium tetrahydrate
- Price: ￥1256.0/25mg ￥3406.0/100mg ￥676.0/10mg ￥2336.0/50mg
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Sivelestat (sodium salt hydrate)
- Price: $200.0/100mg $400.0/250mg $800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Sivelestat (sodium salt hydrate)
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Sivelestat sodium
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: $92/10mM*1mLinDMSO
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