isodiospyrin

Modify Date: 2025-08-25 17:09:37

isodiospyrin structure	Common Name	isodiospyrin
	CAS Number	20175-84-2	Molecular Weight	374.343
	Density	1.5±0.1 g/cm3	Boiling Point	712.0±60.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	398.3±29.4 °C

Use of isodiospyrin

Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3].

Name	Isoldiospyrin
Synonym	More Synonyms

Description	Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
Target	Topoisomerase I
In Vitro	Isodiospyrin (10-40 μM) 不诱导人拓扑异构酶 I (htopo I)-DNA 共价复合物。然而，Isodiospyrin 拮抗 Camptothecin 诱导的 htopo I 介导的 DNA 裂解。Isodiospyrin 结合 htopo I 但不结合 DNA。在 DNA 不存在的情况下，Isodiospyrin 对 htopo I 对剪接因子 2/替代剪接因子的激酶活性具有强烈的抑制作用[1]。 Isodiospyrin 针对革兰氏阳性菌的 MIC 范围为 0.78 至 50 μg/mL。 Isodiospyrin 针对铜绿假单胞菌 ATCC 15443 和伤寒沙门氏菌的浓度范围为 50 至 100 μg/mL。对 M. chelonae 的 MIC 在 6.25 和 25 μg/mL 之间[2]。 Isodiospyrin（30 μM；120-144 小时）显示出 81.4 % 的 P. obscurans 生长抑制。30 μM Isodiospyrin 对 P. viticola 的抗真菌活性为 57.7 %[3]。
References	[1]. Chun-Yuan Ting, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 2003 Nov 15;66(10):1981-91. [2]. B A Adeniyi, et al. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae). Phytother Res. 2000 Mar;14(2):112-7. [3]. Xiaoning Wang, et al. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chem Biodivers. 2011 Dec;8(12):2331-40.

Density	1.5±0.1 g/cm3
Boiling Point	712.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₂H₁₄O₆
Molecular Weight	374.343
Flash Point	398.3±29.4 °C
Exact Mass	374.079041
PSA	108.74000
LogP	3.83
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.707

Hazard Codes	Xi

Isodiospirin

(1,2'-Binaphthalene)-5,5',8,8'-tetrone, 1',4-dihydroxy-2,3'-dimethyl-, (-)-

[1,2'-Binaphthalene]-5,5',8,8'-tetrone, 1',4-dihydroxy-2,3'-dimethyl-, (-)-

1',4-Dihydroxy-2,3'-dimethyl-1,2'-binaphthalene-5,5',8,8'-tetrone

isodiospyrin

[1,2'-Binaphthalene]-5,5',8,8'-tetrone, 1',4-dihydroxy-2,3'-dimethyl-

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: isodiospyrin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: isodiospyrin
Price: ￥5120.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Isodiospyrin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [1,2'-Binaphthalene]-5,5',8,8'-tetrone,1',4-dihydroxy-2,3'-dimethyl-, (1R)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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isodiospyrin

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