isodiospyrin
isodiospyrin structure
|
Common Name | isodiospyrin | ||
|---|---|---|---|---|
| CAS Number | 20175-84-2 | Molecular Weight | 374.343 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 712.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C22H14O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 398.3±29.4 °C | |
Use of isodiospyrinIsodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Isoldiospyrin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase I |
| In Vitro | Isodiospyrin (10-40 μM) 不诱导人拓扑异构酶 I (htopo I)-DNA 共价复合物。然而，Isodiospyrin 拮抗 Camptothecin 诱导的 htopo I 介导的 DNA 裂解。Isodiospyrin 结合 htopo I 但不结合 DNA。在 DNA 不存在的情况下，Isodiospyrin 对 htopo I 对剪接因子 2/替代剪接因子的激酶活性具有强烈的抑制作用[1]。 Isodiospyrin 针对革兰氏阳性菌的 MIC 范围为 0.78 至 50 μg/mL。 Isodiospyrin 针对铜绿假单胞菌 ATCC 15443 和伤寒沙门氏菌的浓度范围为 50 至 100 μg/mL。对 M. chelonae 的 MIC 在 6.25 和 25 μg/mL 之间[2]。 Isodiospyrin（30 μM；120-144 小时）显示出 81.4 % 的 P. obscurans 生长抑制。30 μM Isodiospyrin 对 P. viticola 的抗真菌活性为 57.7 %[3]。 |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 712.0±60.0 °C at 760 mmHg |
| Molecular Formula | C22H14O6 |
| Molecular Weight | 374.343 |
| Flash Point | 398.3±29.4 °C |
| Exact Mass | 374.079041 |
| PSA | 108.74000 |
| LogP | 3.83 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.707 |
| InChIKey | OEEOHKZVBKYMBA-UHFFFAOYSA-N |
| SMILES | Cc1cc2c(c(O)c1-c1c(C)cc(O)c3c1C(=O)C=CC3=O)C(=O)C=CC2=O |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Isodiospirin |
| 1',4-Dihydroxy-2,3'-dimethyl-1,2'-binaphthalene-5,5',8,8'-tetrone |
| isodiospyrin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does Isoldiospyrin have? |
| A: English synonyms of Isoldiospyrin: Isodiospirin, 1',4-Dihydroxy-2,3'-dimethyl-1,2'-binaphthalene-5,5',8,8'-tetrone, isodiospyrin. |
| Q: What is the English name of Isoldiospyrin? |
| A: The English name of Isoldiospyrin is Isoldiospyrin. |
| Q: What is the molecular weight of Isoldiospyrin? |
| A: Molecular weight of Isoldiospyrin is 374.343. |
| Q: What is the SMILES notation of Isoldiospyrin? |
| A: SMILES notation of Isoldiospyrin is Cc1cc2c(c(O)c1-c1c(C)cc(O)c3c1C(=O)C=CC3=O)C(=O)C=CC2=O. |
| Q: What is the CAS number of Isoldiospyrin? |
| A: CAS number of Isoldiospyrin is 20175-84-2. |
| Q: What is the molecular formula of Isoldiospyrin? |
| A: Molecular formula of Isoldiospyrin is C22H14O6. |
| Q: What is the boiling point of Isoldiospyrin? |
| A: Boiling point of Isoldiospyrin is 712.0±60.0 °C at 760 mmHg. |
| Q: What is the polar surface area (PSA) of Isoldiospyrin? |
| A: Polar surface area (PSA) of Isoldiospyrin is 108.74000. |
| Q: What are the uses of Isoldiospyrin? |
| A: Main uses of Isoldiospyrin: Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3]. |
| Q: What is the LogP of Isoldiospyrin? |
| A: LogP of Isoldiospyrin is 3.83. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |