Ginkgolic acid C13:0

Modify Date: 2024-01-02 09:04:48

Ginkgolic acid C13:0 Structure
Ginkgolic acid C13:0 structure
 Common Name Ginkgolic acid C13:0
CAS Number 20261-38-5 Molecular Weight 320.466
Density 1.0±0.1 g/cm3 Boiling Point 449.5±33.0 °C at 760 mmHg
Molecular Formula C20H32O3 Melting Point N/A
MSDS Chinese USA Flash Point 239.8±21.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Ginkgolic acid C13:0


Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity.IC50 value: Inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL); reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL).Target:In vitro: Ginkgolic Acid (C13:0) inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 μg/mL and minimum bactericidal concentration (MBC) of 8 μg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL). Furthermore Ginkgolic Acid (C13:0) disrupted biofilm integrity effectively [1]. In vivo:

 Names

Name 2-hydroxy-6-tridecylbenzoic acid
Synonym More Synonyms

 Ginkgolic acid C13:0 Biological Activity

Description Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity.IC50 value: Inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL); reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL).Target:In vitro: Ginkgolic Acid (C13:0) inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 μg/mL and minimum bactericidal concentration (MBC) of 8 μg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL). Furthermore Ginkgolic Acid (C13:0) disrupted biofilm integrity effectively [1]. In vivo:
Related Catalog
References

[1]. He J, et al. Effects of ginkgoneolic acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mutans in vitro. Folia Microbiol (Praha). 2013 Mar;58(2):147-53.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 449.5±33.0 °C at 760 mmHg
Molecular Formula C20H32O3
Molecular Weight 320.466
Flash Point 239.8±21.9 °C
Exact Mass 320.235138
PSA 57.53000
LogP 8.90
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.519
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DH2944000
CHEMICAL NAME :
Benzoic acid, 2-hydroxy-6-tridecyl-
CAS REGISTRY NUMBER :
20261-38-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H32-O3
MOLECULAR WEIGHT :
320.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>481 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 10,361,1980

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
HS Code 29163990

 Synthetic Route

Methyl 2-hydroxy-6-tridecylbenzoate structure

Methyl 2-hydrox...

CAS#:75808-38-7

~95%

Ginkgolic acid C13:0 Structure

Ginkgolic acid C13:0

CAS#:20261-38-5

Literature: Liebigs Annalen, , # 12 p. 2209 - 2220
2-Hexadecynoic acid, methyl ester structure

2-Hexadecynoic ...

CAS#:63125-05-3

~%

Ginkgolic acid C13:0 Structure

Ginkgolic acid C13:0

CAS#:20261-38-5

Literature: Liebigs Annalen, , # 12 p. 2209 - 2220
Methyl 3-oxo-2-(triphenylphosphoranylidene)hexadecanoate structure

Methyl 3-oxo-2-...

CAS#:63125-03-1

~%

Ginkgolic acid C13:0 Structure

Ginkgolic acid C13:0

CAS#:20261-38-5

Literature: Liebigs Annalen, , # 12 p. 2209 - 2220
Myristoyl Chloride structure

Myristoyl Chloride

CAS#:112-64-1

~%

Ginkgolic acid C13:0 Structure

Ginkgolic acid C13:0

CAS#:20261-38-5

Literature: Liebigs Annalen, , # 12 p. 2209 - 2220
methyl 2-methoxy-6-tridecyl benzoate structure

methyl 2-methox...

CAS#:100485-96-9

~%

Ginkgolic acid C13:0 Structure

Ginkgolic acid C13:0

CAS#:20261-38-5

Literature: Liebigs Annalen, , # 12 p. 2209 - 2220

 Articles1

More Articles
The anti-inflammatory activity of marine natural products--6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate.

Agents Actions 10(4) , 361-7, (1980)

Three novel marine substances, 6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate, isolated from a brown alga, a soft coral and a dictyoceratid sponge respectively, were active af...

 Synonyms

Benzoic acid,2-hydroxy-6-tridecyl
6-n-Tridecylsalicylic acid
Benzoic acid, 2-hydroxy-6-tridecyl-
6-tridecyl anacardic acid
2-Hydroxy-6-tridecylbenzoic acid,6-Tridecylsalicylic acid,Ginkgoneolic acid
Ginkgoneolic acid
6-tridecylsalicylic acid
2-Hydroxy-6-tridecylbenzoic acid
Ginkgolic Acid
6-tridecyl phenol
Ginkgolic acid C13:0
Ginkgolic Acid (C13:0)
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