XMU-MP-2
Modify Date: 2024-04-01 20:45:57
XMU-MP-2 structure
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Common Name | XMU-MP-2 | ||
|---|---|---|---|---|
| CAS Number | 2031152-10-8 | Molecular Weight | 618.652 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C32H33F3N8O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of XMU-MP-2XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM; inhibits the autophosphorylation of BRK Y342 in dose-dependent manner (maximum inhibition at 500 nM), abolishes phosphorylation levels of STAT3 Y705 and STAT5 Y694; blocks proliferation and survival of BRK-transformed Ba/F3 cells with IC50 of 29.7 nM; cooperates strongly with HER2 inhibitor or ER blockade to block breast cancer cell proliferation in vitro and in vivo. |
| Name | N-{3-[7-{[6-(4-Hydroxy-1-piperidinyl)-3-pyridinyl]amino}-1-methyl-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide |
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| Synonym | More Synonyms |
| Description | XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM; inhibits the autophosphorylation of BRK Y342 in dose-dependent manner (maximum inhibition at 500 nM), abolishes phosphorylation levels of STAT3 Y705 and STAT5 Y694; blocks proliferation and survival of BRK-transformed Ba/F3 cells with IC50 of 29.7 nM; cooperates strongly with HER2 inhibitor or ER blockade to block breast cancer cell proliferation in vitro and in vivo. |
|---|---|
| References | References 1. Jiang J, et al. Cancer Res. 2017 Jan 1;77(1):175-186. View Related Products by Target Breast Tumor Kinase (BRK;PTK6) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C32H33F3N8O2 |
| Molecular Weight | 618.652 |
| Exact Mass | 618.267883 |
| LogP | 3.16 |
| Index of Refraction | 1.659 |
| Benzamide, N-[3-[1,4-dihydro-7-[[6-(4-hydroxy-1-piperidinyl)-3-pyridinyl]amino]-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- |
| N-{3-[7-{[6-(4-Hydroxy-1-piperidinyl)-3-pyridinyl]amino}-1-methyl-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: XMU-MP-2
- Price: Negotiable
- Purity: 99.29%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: XMU-MP-2
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: XMU-MP-2
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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